{"id":1027,"date":"2023-11-21T12:30:14","date_gmt":"2023-11-21T12:30:14","guid":{"rendered":"https:\/\/farmina.site\/small-molecule-drug-shows-promise-in-rare-disease\/"},"modified":"2024-02-02T13:28:23","modified_gmt":"2024-02-02T13:28:23","slug":"small-molecule-drug-shows-promise-in-rare-disease","status":"publish","type":"post","link":"https:\/\/farmina.site\/ro\/small-molecule-drug-shows-promise-in-rare-disease\/","title":{"rendered":"Medicamentul cu molecule mici arat\u0103 promi\u021b\u0103tor \u00een bolile rare"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u00centr-un studiu de faz\u0103 II, medicamentul cu molecule mici CBL-514 a demonstrat o reducere semnificativ\u0103 a dimensiunii lipomului \u0219i ameliorarea durerii \u00een boala Dercum, o tulburare rar\u0103.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"533\" src=\"https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-6-1024x533.jpg\" alt=\"\" class=\"wp-image-240\" srcset=\"https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-6-1024x533.jpg 1024w, https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-6-300x156.jpg 300w, https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-6-768x400.jpg 768w, https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-6-1536x799.jpg 1536w, https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-6.jpg 1614w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n\t<ol>\n\n\t\t\n\t\t\t\t\t\t\t<li>\n\t\t\t\t\t<p><strong>Rezultatele studiului de faz\u0103 II CBL-514<\/strong><\/p>\n<p>Studiul de faz\u0103 II CBL-0201DD care evalueaz\u0103 primul medicament cu molecule mici CBL-514 pentru boala Dercum, o afec\u021biune rar\u0103, a demonstrat o eficacitate semnificativ\u0103 \u00een reducerea dimensiunii lipomului \u0219i a clearance-ului complet.<\/p>\n\t\t\t\t<\/li>\n\t\t\t\n\t\t\n\t\t\t\t\t\t\t<li>\n\t\t\t\t\t<p><strong>Studiul pentru boala Dercum<\/strong><\/p>\n<p>A evaluat eficacitatea \u0219i siguran\u021ba injec\u021biilor cu CBL-514 la doisprezece participan\u021bi. Ca obiectiv primar, dimensiunea lipoamelor dureroase \u00een grupul cu doze mari a fost redus\u0103 cu 51,3% \u0219i 54,7% la 4 \u0219i 8 s\u0103pt\u0103m\u00e2ni dup\u0103 tratamentele cu CBL-514.<\/p>\n<p><strong>Progresie clinic\u0103 viitoare pentru primul medicament cu molecule mici din clas\u0103<\/strong><\/p>\n<p>Dimensiunea lipoamelor dureroase \u00een grupul cu doz\u0103 mic\u0103 a fost redus\u0103 cu 40,0% \u0219i 34,7% la 4 \u0219i 8 s\u0103pt\u0103m\u00e2ni dup\u0103 tratamentele cu CBL-514.<\/p>\n\t\t\t\t<\/li>\n\t\t\t\n\t\t\n\t\t\t\t\t\t\t<li>\n\t\t\t\t\t<p>90,3% din lipoamele dureroase din grupul cu doze mari<\/p>\n<p>A ar\u0103tat o reducere a dimensiunilor dup\u0103 tratamentele cu CBL-514 \u00een compara\u021bie cu valoarea ini\u021bial\u0103. La pacien\u021bii cu boala Dercum care au primit doza mare, 64,5% dintre lipoamele dureroase au demonstrat clearance-ul complet sau o reducere a dimensiunilor de peste 50% dup\u0103 tratamentele cu CBL-514, comparativ cu valoarea ini\u021bial\u0103.<\/p>\n<p>1. 38,7 la sut\u0103 din lipoamele dureroase din grupul cu doze mari<br \/>\n2. Raportul de cercetare de pia\u021b\u0103 global\u0103 a bolii Dercum<br \/>\n3. M\u0103rimea pie\u021bei globale a tratamentului bolii Dercum \u00een 2021 a fost de 11,3 miliarde USD<\/p>\n<p>n<\/p>\n\t\t\t\t<\/li>\n\t\t\t\n\t\t\n\t<\/ol>\n\n\t\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"533\" src=\"https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-7-1024x533.jpg\" alt=\"\" class=\"wp-image-250\" srcset=\"https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-7-1024x533.jpg 1024w, https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-7-300x156.jpg 300w, https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-7-768x400.jpg 768w, https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-7-1536x799.jpg 1536w, https:\/\/farmina.site\/wp-content\/uploads\/2023\/11\/img-7.jpg 1614w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tratamentul bolii Dercum<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dimensiunea pie\u021bei globale a tratamentului bolii Dercum \u00een 2021 a fost de 11,3 miliarde USD. Cu o rat\u0103 de cre\u0219tere anual\u0103 compus\u0103 (CAGR) de 6,76%, pia\u021ba global\u0103 a tratamentului bolii Dercum \u00een 2030 este estimat\u0103 s\u0103 creasc\u0103 la 19,95 miliarde USD.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Eficacitate \u0219i siguran\u021b\u0103 detaliate<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiul bolii Dercum CBL-0201DD<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Jurnalul de boli rare<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pe baza rezultatelor cercet\u0103rii,<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Concluzii<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Caliway pl\u0103nuie\u0219te \u00een prezent pentru CBL-0202DD studiul de faz\u0103 IIb aplica\u021bie IND pentru a investiga \u00een continuare CBL-514.<\/p>\n","protected":false},"excerpt":{"rendered":"\u00centr-un studiu de faz\u0103 II, medicamentul cu molecule mici CBL-514 a demonstrat o reducere semnificativ\u0103 a dimensiunii lipomului \u0219i ameliorarea durerii \u00een boala Dercum, o tulburare rar\u0103. Tratamentul bolii Dercum Dimensiunea pie\u021bei globale a tratamentului bolii Dercum \u00een 2021 a fost de 11,3 miliarde USD. Cu o rat\u0103 de cre\u0219tere anual\u0103 compus\u0103 (CAGR) de 6,76%, [&hellip;]","protected":false},"author":1,"featured_media":240,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-1027","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-ro"],"acf":[],"_links":{"self":[{"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/posts\/1027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/comments?post=1027"}],"version-history":[{"count":5,"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/posts\/1027\/revisions"}],"predecessor-version":[{"id":1041,"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/posts\/1027\/revisions\/1041"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/media\/240"}],"wp:attachment":[{"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/media?parent=1027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/categories?post=1027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/farmina.site\/ro\/wp-json\/wp\/v2\/tags?post=1027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}